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Lvhuajia Huanshipian or Potassium Chloride Sustained-release Tablets for premature beats or tachyarrhythmia hypokalemia
Lvhuajia Huanshipian or Potassium Chloride Sustained-release Tablets for premature beats or tachyarrhythmia hypokalemia
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Potassium Chloride Sustained-release Tablets
Lvhuajia Huanshipian
Lv Hua Jia Huan Shi Pian
氯化钾缓释片
FUNCTION and INDICATIONS
1.Treatment of hypokalemia caused by various causes of hypokalemia, such as insufficient food intake, vomiting, severe diarrhea, application of potassium excretion diuretics, hypokalemic familial periodic paralysis, long-term use of glucocorticoids and supplementation of hypertonic glucose.
2.Prevention of hypokalemia When patients have potassium loss, especially if hypokalemia is harmful to patients (such as patients with digitalization), preventive potassium supplementation is required, such as little food intake, severe or chronic diarrhea, long-term use of adrenocortical hormone, hypokalemic kidney disease, and Bartter's syndrome.
3.Digitalis poisoning causes frequent, multi-source premature beats or tachyarrhythmia.
INGREDIENTS
POTASSIUM CHLORIDE.
DESCPRIPTION
White sugar-coated tablet,contains an appropriate amount of excipients.
SPECIFICATION AND PACKAGE
0.5g*24 tablets/box.
USAGE AND DOSAGE
Adults take 0.5g~1g each time, 2~4 times a day, after meals, and adjust the dose according to the needs of the disease. Generally, the maximum daily dose for adults is 6g. For patients with gastrointestinal reactions to oral tablets, oral solution can be used and diluted in cold boiled water or drinks for oral administration.
REFERENCES
ADVERSE REACTION
1.Oral administration may occasionally cause gastrointestinal irritation symptoms, such as nausea, vomiting, pharyngeal discomfort, chest pain (esophageal irritation), abdominal pain, diarrhea, and even peptic ulcer and bleeding. It is more likely to occur in patients with fasting, large dose and original gastrointestinal diseases.
2.Hyperkalemia. It is easy to occur when excessive use or original renal function is damaged. The symptoms include weakness, fatigue, numbness of hands, feet, mouth and lips, anxiety of unknown reasons, blurred consciousness, dyspnea, heart rate slowing, arrhythmia, conduction block, and even cardiac arrest. The ECG showed high and sharp T wave, and the P-R interval was gradually prolonged. P wave disappeared, QRS wave widened, and sine wave appeared. Once hyperkalemia occurs, it should be treated immediately. (1) Stop potassium supplement immediately and avoid using potassium diet, drugs and potassium sparing diuretics. (2) Intravenous infusion of high concentration glucose injection and insulin to promote K+entry into cells, 10%~25% glucose injection 300~500ml per hour. Add 10 units of regular insulin per 20g of glucose. (3) If there is metabolic acidosis, 5% sodium bicarbonate injection should be used immediately, and 11.2% sodium lactate injection can be used for those without acidosis, especially for those with QRS wave widening. (4) Use calcium to counteract the cardiotoxicity of K+. When the ECG indicates P wave deficiency, QRS wave widening, arrhythmia, and digitalis are not used, 10ml of 10% calcium gluconate injection can be given intravenously for 2 minutes, and repeated use every 2 minutes if necessary. (5) Oral potassium reducing resin can block the absorption of intestinal K+and promote intestinal K+excretion. (6) Severe hyperkalemia with renal failure. Hemodialysis or peritoneal dialysis is feasible, while hemodialysis is effective and fast in removing K+. (7) Apply loop diuretics and supplement physiological saline when necessary.
CONTRAINDICATIONS
Contraindicated in patients with hyperkalemia or patients with little urine volume and urination.
Drugs for pregnant women and lactating women
Uncertainty.
Children's medication
Medication for elderly patients
The ability of kidney to clear K+in the elderly is decreased, and hyperkalemia is more likely to occur when potassium salt is used. Blood potassium should be checked during medication.
Overdose
See hyperkalemia with adverse reactions.
Warning
This product should be swallowed and not chewed. 1.Use with caution in the following cases: (1) Metabolic acidosis with oliguria; (2) The function of adrenal cortex is weakened; (3)Acute and chronic renal failure; (4)Acute dehydration can cause urinary volume reduction and urinary K+excretion reduction in severe cases; (5)Familial periodic paralysis; Hypokalemic paralysis should be supplemented with potassium, but it is necessary to identify hyperkalemic or normal blood potassium periodic paralysis; (6) Chronic or severe diarrhea can cause hypokalemia, but at the same time it can cause dehydration and hyponatremia, and cause prerenal oliguria; (7)People with gastrointestinal obstruction, chronic gastritis, ulcerative disease, esophageal stricture, diverticulum, lack of intestinal tension, and ulcerative enteritis should not take potassium supplements orally. Therefore, when potassium stimulates the gastrointestinal tract, it can aggravate the disease; (8)Conduction block arrhythmia, especially when using digitalis; (9)Large-area burns, muscle trauma, severe infection, and severe hemolysis within 24 hours after major surgery can cause hyperkalemia; (10)Congenital adrenocortical hyperplasia with insufficient secretion of mineralocorticoid. (11)During medication, the following follow-up examinations should be performed:① blood potassium; ②ECG;③ Blood magnesium, sodium and calcium; ④Acid-base balance index; ⑤Renal function and urine volume..
DRUG INTERACTION
1.Adrenal glucocorticoids, especially those with obvious effects of glucocorticoids, adrenocorticotropic hormone and adrenocorticotropic hormone (ACTH), can promote the excretion of potassium in urine and reduce the efficacy of potassium salt when used together.
2.Anticholinergic drugs can aggravate the gastrointestinal irritation of oral potassium salts, especially potassium chloride.
3.Non-steroidal anti-inflammatory and analgesic drugs aggravate the gastrointestinal reaction of oral potassium salt.
4.When the blood in stock is used together (the potassium content is 30mmol/L under the stock of 10 days, and 65mmol/L above the stock of 10 days), and the potassium containing drugs and potassium sparing diuretics are taken, the chances of hyperkalemia increase, especially those with renal function damage.
5.Angiotensin converting enzyme inhibitor and cyclosporin can inhibit the secretion of aldosterone, reduce the excretion of potassium in urine, and prone to hyperkalemia when used together.
6.Heparin can inhibit the synthesis of aldosterone, reduce the excretion of potassium in urine, and is prone to hyperkalemia when used together; In addition, heparin can increase the chance of gastrointestinal bleeding.
7.Slow-release potassium salt can inhibit intestinal absorption of vitamin B12.
PHARMACOLOGIC ACTION
Potassium is the main cation in the cell, and its concentration is 150~160mmol/L; The main cation outside the cell is sodium ion, and the concentration of potassium is only 3.5~5 mmol/L. The body mainly depends on the Na+- K ± ATPase on the cell membrane to maintain the difference between the concentration of K+and Na+in the cell. The acid-base balance in the body has an impact on potassium metabolism. For example, H+enters the cell during acidosis. In order to maintain the potential difference of the cell, K+is released outside the cell, causing or aggravating hyperkalemia. The metabolic disorder will also affect the acid-base balance. Normal intracellular and extracellular potassium concentration and concentration difference are closely related to some important functions of cells, including maintaining carbohydrate metabolism, glycogen storage, protein metabolism, intracellular osmotic pressure and acid-base balance, myocardial excitability and conductivity; It can maintain the normal tension of skeletal muscle and nerve impulse conduction, and increase the tension of intestinal, uterine and bronchial smooth muscle.
Pharmacokinetics of this paragraph
90% of potassium is excreted by kidney and 10% by intestine.
STORAGE
Hermetically sealed,keep in cool and dry places.
PERIOD OF VALIDITY
24 months.
CERTIFICATE NO
Stage Food and Drug Administration Approval numberH20178003.
Manufactured
Guangzhou Yudong Health Pharmaceutical Co., Ltd
Tips: Please read the directions for use in retail or directed by physician.
Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive.
General Cautions
Keep away from animals and children.This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health.